Synthesis, Characterization and Antimicrobial Screening of Some Newly Synthesized Glycosides Derivatives
DOI:
https://doi.org/10.32628/IJSRCH251154Keywords:
Glycosides, Dithiazolidine, Antimicrobial activity, Synthetic glycosides, Staphylococcus aureus, Escherichia coliAbstract
Glycosides are naturally occurring compounds comprising an organic aglycone linked to one or more sugar moieties. They are widely distributed in medicinal plants and exhibit diverse pharmacological activities, including cardiotonic, purgative, analgesic, antiarrhythmic, and demulcent effects. In this study, a series of novel glycosidic dithiazolidine derivatives were synthesized, namely 4-Phenyl-5-o-chlorophenylimino-3-S-tetra-O-acetyl-α-D-glucosyl-1,2,4-dithiazolidine (a), 4-Phenyl-5-m-chlorophenylimino-3-S-tetra-O-acetyl-α-D-glucosyl-1,2,4-dithiazolidine (b), 4-Phenyl-5-o-methoxyphenylimino-3-S-tetra-O-acetyl-α-D-glucosyl-1,2,4-dithiazolidine (c), and 4-Phenyl-5-m-methoxyphenylimino-3-S-tetra-O-acetyl-α-D-glucosyl-1,2,4-dithiazolidine (d). The synthesized compounds were evaluated for their antimicrobial activity against Staphylococcus aureus, Enterococci, Escherichia coli, and Pseudomonas aeruginosa. Preliminary screening indicated that some derivatives exhibited notable inhibitory effects, particularly against Gram-positive bacteria. These findings suggest that the synthesized glycosidic dithiazolidine analogs possess potential as antimicrobial agents, combining structural versatility with pharmacological relevance.
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